Phyllanthus Amarus: A Review Sonia Verma, Hitender Sharma, Munish Garg Abstract Herbs have always formed an integral part of human health and are used in the treatment of several human diseases. One of such species which have wide patronage of use is Phyllanthus amarus. This herb is in traditional medicine for more than 3,000 years Chanca piedra pills or capsules contain anywhere from 500 to 1,600 mg of the herb per dose, and liquid extracts contain a similar amount. It's difficult to tell how much of the herb you would.. . APAE =Aqueous Phyllanthus amarus Extract. On the basis of above result's that aqueous extract for further studies and doses 100, 200 and 400 mg/kg. Preliminary phytoconstituents Table 3: The preliminary phytochemical analysis of extract revealed that the presence of various phyto constituents In a clinical study, 37 patients with chronic viral hepatitis B, were treated with daily dose of 600mg of Bhuiamala for 30 days. 59% of the patients lost the HBsAg two weeks after the end of the treatment. HBsAg is the surface antigen of the hepatitis B virus (HBV). It indicates current hepatitis B infection
leaf of Phyllanthus amarus causes a dose- and time- dependent decreases in the biochemical parameters such as: AST, ALT, Urea, Uric acid, Creatinine, Total cholesterol, Protein, Alkaline, Acid, and Prostatic Phosphatases (Fig I ,2 and 3).These effects were statistically significant at P <0.05 using student t-test Normally, Liv.52 plain in dosage of 2 tablets twice daily or Liv.52 DS in dosage of 1 tablet twice daily for one to two months is sufficient to normalize the liver enzymes
According to a 2018 study in the International Brazilian Journal of Urology, 56 adults with kidney stones were instructed to drink an infusion tea made with Phyllanthus niruri twice daily for 12 weeks. Each infusion was made with 4.5 grams of the dried herb steeped in 250 milliliters (1 cup) of boiling water Until about 1980, taxonomists placed a number of species, including this one, under Phyllanthus niruri L. Where the name Phyllanthus niruri has been applied in older literature to African or Asian specimens, usually Phyllanthus amarus is intended, but sometimes also Phyllanthus debilis, Phyllanthus fraternus, Phyllanthus maderaspatensis or Phyllanthus rotundifolius
Thirty-four received Phyllanthus amarus 600 mg per day for 30 days and 31 received placebo in identical capsules. The conversion rate of HBsAg was 6 per cent in the study group at day 30 Oral administration of P. amarus extract (800 mg/kg) 1 h before oral MDZ increased the C (max) and AUC (0--∞) of MDZ by 3.9- and 9.6-fold and decreased the clearance by 12%, but did not alter the pharmacokinetics of intravenous MDZ The usual dose of P. amarus used in studies is 600 to 900 mg daily. P4 There are no indications that P. amarus is toxic when used at recommended doses, but comprehensive safety studies have not been performed. 14 In double-blind studies, significant side effects have not been reported Taesotikul, T., et al. Effects of Phyllanthus amarus on the pharmacokinetics of midazolam and cytochrome P450 activities in rats. Xenobiotica. 2012 Jul; 42(7): 641-8. Taesotikul, T., et al. Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based.
Several studies suggest that Phyllanthus urinaria works better than the related species p. amarus, p. debilis and p. niruri in the treatment of hepatitis B. An equally important action is the use against kidney stones (renal calculi), urinary tract- and bladder infections The Phyllanthus amarus plant suppresses HBV mRNA transcription in vitro and exhibits therapeutic potential in chronic HBV carriers, although further work is necessary to define its mechanism of action. Analysis in HuH‐7 cells with transfected plasmids using a luciferase reporter showed that P. amarus specifically inhibited HBV enhancer I activity. To identify the mechanism of this HBV.
The radioprotective effect of an extract of the plant Phyllanthus amarus (P. amarus) was investigated in adult BALB/c mice. P. amarus extract (750 mg/kg b.wt and 250 mg/kg b.wt) was administered orally to mice for five days prior to whole body radiation (6 Gy) and for one month after radiation Phyllanthus amarus is a leafy herbal plant found in tropical regions in the Americas, Africa, India, China and South East Asia. Commons names for this plant include gale of the wind, carry me seed, seed on the leaf, pick-a-back, Bhuiavla (Hindi), Bhuiamla (Bengali), stonebreaker, dukung anak (Malay)
Therefore, the aim of the present study was to investigate the mechanism action of diuretic effects of an ethanolic fraction of Phyllanthus amarus (EFPA) in rats. METHODS: Effects of EFPA on urinary excretion were carried out for doses ranging from 5 to 80 mg/kg given by intraperitoneal injection (i.p.) and compared with that induced by. Phyllanthus amarus (PA) has been documented to have neuroprotective potential. Aim: To evaluate the potential of standardized extract of PA and its possible mechanism of action against the Pentylenetetrazol (PTZ)-induced convulsion and kindling associated post-ictal depression in experimental mice Phyllanthus species (family; Euphorbiaceae) have been intensively studied for their immunomodulating effects due to their wide-ranging uses to treat immune-related diseases in indigenous medicine, which are primarily lack of scientific basis. The focuses of this review are on the significance of Phyllanthus species and their bioactive metabolites particularly corilagin (1), geraniin (2. Phyllanthus has a positive effect on antiviral activity and the liver biochemistry in chronic HBV (Hepatitis B Virus) infection. Dosage Tincture: 1 - 4 ml / daily. Infusion (herbal tea): 1 - 2 cups / day (1 - 2 teaspoons / cup) Infusions (teas): Use hot, not boiling water. Phyllanthus should be steeped for 1 - 6 minutes Each one (1) capsule contains: Phyllanthus (Phyllanthus amarus) leaf extract 200 mg Milk Thistle (Silybum marianum) seed extract (standardized to 80% silymarin) 200 mg Dandelion (Leontodon taraxacum) root extract 200 mg Other ingredients: Cellulose, stearic acid Suggested Use: As a dietary supplement, 1 capsule, two or three times daily with meals
Results: The lower doses of the tannin rich extract (PAHME) of the P. amarus possess significant anxiolytic activity compared to lignin rich (PAME) and aqueous extracts (PAAE), while at a higher dose (400mg/kg) the results of all three extracts appears to be potentially sedative. While the molecular docking studies support these probable. Phyllanthus amarus is highly valued in African traditional medicine for its hepatoprotective, anti-inflammatory and several related ailments. Aim: The aim of the present study was to investigate the effects of the administration of P. amarus on garlic-induced hepatotoxicity in rats Phyllanthus niruri has extensive medicinal properties and has long history in the health care system of tropical countries. The plant is known in traditional health care systems. P. niruri is commonly known as Chanca pedra (or) stone breaker
Phyllanthus amarus. Plants of the Phyllanthus genus, found in tropical and subtropical countries, contain alkaloids, flavonoids, lignans, and terpenes. They have been used in India and China to treat diabetes, diarrhea, hepatitis B, and urinary tract conditions  Specimens of the genus Phyllanthus are widely used as traditional medicines and consist of more than 1,000 species found in tropical and subtropical countries of the world.Phyllanthus amarus Schum & Thorn is well known since ancient times (about 3000 years) [5,8,9]. This plant is a small herb (30cm-60cm) commonly called stone breaker, wind breaker, carry me seed, and many other folk designations Chanca piedra is an herb. The whole plant is used to make medicine. Chanca piedra is used for various disorders of the urinary tract including infections, pain and swelling (inflammation), kidney stones, and discharge from the urethra or vagina.It is also used for digestive tract disorders including gas, loss of appetite, stomachache, intestinal infections, constipation, and dysentery The health benefits of chanca piedra, also known as phyllanthus niruri, are many. Chanca piedra is a common tropical plant found in areas along the coast as well as the Amazon rainforest. It is usually found in abundance, with spreading tendencies much like common weeds
Phyllanthus niruri, or Chanca Piedra, is a small annual herb that grows and spreads much like a weed; it is native to the rainforests of the Amazon and other tropical areas, including the Bahamas, southern India, and China.Two other species, Phyllanthus amarus and Phyllanthus sellowianus, are closely related to P. niruri in appearance, phytochemical structure, and history of use, but are. Phyllanthus amarus, a commonly used medicinal herb, was investigated for possible herb-drug interactions.The effect on CYP3A-mediated drug metabolism in rats after single dose administration of P. amarus extract was investigated using midazolam (MDZ) as a probe substrate. The effect of multiple dose administration of P. amarus extract on activity and expression of various CYP isoforms were. To study the effect of P. amarus on a leukocyte migration assay, neutrophils were purified from the blood of rats that were pretreated with or without the 80% ethanol extract of P. amarus. fMLP induced neutrophil chemotaxis under the control conditions, and pretreatment of the rats with extract of P. amarus at doses ranging from 100 to 400 mg. Botanical names: Phyllanthus niruri, Phyllanthus Caroliniensis How It Works Phyllanthus primarily contains lignans (e.g., phyllanthine and hypophyllanthine), alkaloids, and flavonoids (e.g., quercetin). Phyllanthus blocks DNA polymerase, the enzyme needed for the hepatitis B virus to reproduce. In one study, 59% of.. 2.7 Phyllanthus niruri L. P. niruri is an annual small herb available in the subtropical and tropical parts of world. The use of the genus Phyllanthus in traditional remedies as a hepatoprotective is common. According to scientists, P. amarus and P. niruri are often confused and many of the plant experts have used both names interchangeably or.
The standard dose used in experiments is 1-3 g fruit powder. Add it to juices, smoothies, or your morning health shot, but try and spread it out through the day 7. Bhumyamalaki. Certain plants under the Phyllanthus species, such as Phyllanthus amarus and Phyllanthus niuri, have been found to have protective effects on the liver CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Phyllanthus amarus Schum. & Thonn. is an important plant of Indian Ayurvedic system of medicine and its various parts were used traditionally for the treatment of problems related to stomach, wounds, liver and spleen. The objective of this study was to evaluate the anti-inflammatory activity of hexane (PAHE), ethyl. The sperm pH was not significantly (p>0.05) affected by Phyllanthus amarus among the different treatment groups in the experimental animals. Conclusion: Findings from the present study indicate that Phyllanthus amarus possesses a dose-dependent anti-fertility activity in amale albino rats under a sub-chronic course of administration Clinical trial studies of P. amarus at dosage up to 600 mg/d for 30 d of dried whole plant were reported to decrease hepatitis B surface antigen (Thyagarajan et al., 1988; Blumberg et al., 1990). Hepatitis virus is one of the causative agents of liver cancer (Beasley, 1988; Yu and Chen, 1994)
Phyllanthus amarus is widely grown in this sub-continent and used traditionally to treat many common ailments. In the present study, lignan rich fraction of P. amarus extract was used on cervical. Apply Now. Home; The University. About Al-Hikmah University; Members of Board of Trustee
Background It's overwhelmingly accounted that there is high prevalence of high salt diet related adiposity and metabolic antioxidant infringement worldwide. The present study thus aimed to establish the folkloric use of Phyllantus amarus by traditional practitioners and.. GROHBIG Grohbig regulates and tones up liver functions, it improves FCR, growth, and weight gain in broilers, optimizes egg production, eggshell quality, improves laying performance in layers and breeders Hepatitis B is one of the major burdens for health services and is the leading cause of morbidity and mortality from cirrhosis of liver and hepatocellular carcinoma. Current treatment strategies using nucleos(t)ide analogue reverse-transcriptase inhibitors or interferons are targeted for the long-term suppression of hepatitis B DNA. However, functional cure of hepatitis B infection (HBsAg.
These systems have prescribed texts in which the symptoms, disease diagnosis, drugs to cure, preparation of drugs, dosage and diet regimes, daily and seasonal regimens. Non-institutional systems, whereas, do not have such records and or practiced by rural and tribal peoples across India. Phyllanthus amarus. Question 21. The active principle. Phyllanthus niruri is a widespread tropical plant commonly found in coastal areas, known by the common names gale of the wind, stonebreaker or seed-under-leaf. It is in the genus Phyllanthus of the family Phyllanthaceae Description. Phyllanthus niruri. It grows 50-70 cm (20-28 in) tall and bears ascending herbaceous branches.. Taking a single dose of expired Phyllanthus Amarus is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions
Phyllanthus amarus (PA) is a small herb indigenous to Amazon Basin .It is well known for its medicinal properties and widely used by oriental countries. It is extract at a dose 600mg per day for 30 days and thirty on received placebo in identical capsules, at day 30 the conversion rate of HbsAg was 6% in th Nephroprotective effect of Phyllanthus amarus The aqueous extract of Phyllanthus amarus at doses of 200 mg and 400 mg/kg/day for 14 days, were found to protect against the nephrotoxic effect of paracetamol and gentamicin in rat, by maintaining the level of blood urea nitrogen and serum creatinin Phyllanthus (Phyllanthus amarus) An Ayurvedic herb , Phyllanthus has been used in connection with secondary hepatitis and other pain, and in Ayurvedic medicine for over 2,000 years. It has a wide number of traditional uses: employing the whole plant for jaundice , gonorrhea, frequent menstruation, and diabetes and using it topically as a. dose of 10 mg/kg midazolam with 10 mL of water. In phase 2, after a 1-week washout period, the animals were orally admin-istered with 500 mg/kg P. amarus extract once a day (o.d.) for 7 days and the last dose in the morning on day 8, one hour before midazolam administration. Blood samples (2 mL) wer A dose of 3 to 6 g/day of powdered emblica has been extrapolated from a vitamin C 1 g/day dose.36. Jeena KJ, Joy KL, Kuttan R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett. 1999;136(1):11-16.10211933
Phyllanthus amarus is one of the most important medicinal plant in tropical and subtropical nations which are used for stomach, liver, kidney and spleen diseases treatment. This work involves the elucidation of the phytochemical constituents in 70% ethanolic leaf extract of P. amarus. Phytochemical screening, quantitativ ABSTRACT . Background: Phyllanthus amarus is a herbal agent commonly used for the treatment of several diseases including gastric ones. A systematic study about its toxic effects when chronically and excessively administered is still lacking. Aim: This study investigates the histological effects of chronic administration of the herb on the stomach and the duodenum of adult Wistar rats of both. Chanca piedra (Phyllanthus niruri) is a plant native to tropical coastal areas.The entire plant is used to produce an herbal supplement used in teas, capsules, liquid extracts, and tablets. The. PN Phyllanthus amarus - ลูกไต้ใบ 100 capsules. Content: Phyllanthus amarus Schum.& Thonn Extract. € 6.55 . for the concomitant treatment of liver diseases. Dosage: 1 - 3 capsules, 3 times per day. Phyllanthus amarus for liver health: The popularity of herbal remedies is increasing and many patients with liver disease use them The acute toxicity study indicated a single dose of P. amarus (25, 50 and 75 mg/kg, p.o.) or SL (Silymarin, 5 mg/kg), 24 h before ethanol (5 g/kg, p.o) in male Wistar rats lowered the ethanol-induced levels of AST and/or ALT. The 75 mg/kg P. amarus dose gave the best result similar to SL
Phyllanthus amarus is a tropical shrub indigenous to the rainforest of Amazon and other tropical areas of the world (Samraj, 2001). It belongs to the family Euphobiacea and classified as a type of Phyllanthus nururi (Kassuya et al., 2005). The plant has been valued in many countries for its medicinal properties and curativ The study was designed to examine the acute toxicity of Phyllanthus amarus. Aerial parts of Phyllanthus amarus were collected from Avsari Forest Park, the fresh juice of aerial parts were prepared and used for study. The acute toxicity study is carried out as per OECD guideline in Swiss mice weighing 35 to 50 gm. The dose of 2, 4, 6 and 8gm/kg. P. amarus . at dose rate of 200 mg/kg body weight and Group IV animals were administered aqueous extract of . P. amarus . at dose rate of 400 mg/kg body weight. GroupV animals were administered alcoholic extract of . P. amarus . at a dose of 200 mg/kg body weight, and GroupVI animals were adminis - tered extract of . P. amarus . at a dose rate. Phyllanthin is one such lignan from Phyllanthus amarus as well as different Phyllanthus species. Phyllanthin was evaluated as a chronic intervention (12 weeks) in mice, at a daily dose of 2 and 4 mg kg −1 of body weight along with a lard based high fat diet (HFD). Phyllanthin protected against HFD induced weight gain and adiposity
Phyllanthus amarus. Linn. B. Joseph and S.J. Raj. ABSTRACT. Phyllanthus amarus (Euphorbiaceae) is a widely distributed small erect, tropical annual herbal whose stem has green capsule and grows upto 10-60 cm tall. The plant is bitter, astringent, cooling, diuretic, stomachic, febrifuge and antiseptic. It is popular in indigenious system of. A mixture (1:1) of Phyllanthin and Hypophyllanthin isolated from Phyllanthus amarus (P. amarus) exhibited antitumor activities against Ehrlich Ascites Carcinoma in Swiss albino mice. Animals were pre-treated orally with the extract at a dose of 25mg/kg, 50 mg/kg, 100mg/kg body weight and then after 24hrs after EAC (at a dose of 2 x 106 cell It can be further studied for optimum dosage to be used as a future of anti-anxiety drug development or as a standardized Phytomedicine. Keywords: Phyllanthus amarus, anxiety, phyllanthin, hypophyllanthin, corilagin, lignans. Affiliation: Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, 415404, Department of Pharmacology. Phyllanthus niruri is a plant with possible health benefits. It may play a role in treating ulcers and urinary tract stones, for example. However, due to a lack of research, there is insufficient.
Phyllanthus sellowianus, Phyllanthus fraternus and Phyllanthus amarus. Phyllanthus amarusis a small erect annual herb that grows up to 15 ñ 50 cm high. It is indige-nous to the rainforest of the Amazon and other trop-ical areas of the world including the Bahamas, southern India, and Africa (4). Phyllanthus amarus has a long history of use i The indigenous herb Phyllanthus amarus grows upto 10-60 cm tall is widely spread in our country. Phyllanthus amarus is a small weed, locally known as Bhumyamalaki. P. amarus is an important plant of Indian Ayurvedic system of medicine which is used in the problems of stomach, genitourinary system, liver, kidney and spleen
A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential. Med Res Rev. 18(4):225-58. Thyagarajan SP, Subramanian S, Thirunalasundar T, et al. Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. Lancet. 1988;2:764-766 Phyllanthus amarus (Schum and Thonn) is a weed plant in the family Euphorbiaceae, and is a widely distributed small, erect tropical annual herbal whose stem has green capsule and grows upto 10-60 metres tall (Burkill, 1985; Joseph and Raj, 2011) the Phyllanthus genus was conducted (which classified P. amarus as a type of P. niruri). Phyllanthus niruri is an herb of Euphorbiaceae family that grows up to 60 cm. Phyllanthus means leaf and flower because the flower, as well as the fruit, seems to become one with the leaf
Ethnopharmacologists know Phyllanthus amarus as a plant that has shown undeniable anti-inflammatory and anti-cancer effects in animal studies. Researchers at the University of Malaya write in Pharmaceutical Biology that they have found a more profanse application for Phyllanthus amarus.A remarkably low dose of the plant reduces hangover symptoms after excessive alcohol consumption Phyllanthus amarus (P. amarus) and . Momordica charantia (M. charantia) were selected for this study and evaluating their influence on the activity of major drug metabolizing enzyme CYP450 isoforms was the primary focus of this study. Pregnane X receptor (PXR) is a nuclear receptor that acts as a transcriptio Background:Phyllanthus amarus (PA) is widely studied for its hepatoprotective properties but has recently received increasing attention due to its diverse anti-inflammatory effects. However, the effects of PA in modulating immune responses in the central nervous system leading to protection against functional changes remain unexplored. Therefore, we sought to examine the protective effects of. In a study from India, P. amarus 500 mg was prepared in capsules given orally three times daily. 15 Other groups used different Phyllanthus species at dosages ranging from 300 to 900 mg three times daily. 8 Owing to the inconspicuous anti‐viral effects in previous studies and the good safety profile as reported in the past, we evaluated three. The ethanol extract of Phyllanthus amarus (Schum and Thonn), a plant of ethnomedicinal importance, was formulated into herbal cream and ointment and evaluated using physicochemical, safety and antimicrobial properties. The extract was obtained by maceration and the antimicrobial properties tested on clinically isolated pathogenic bacteria (Staphylococcus aureus and Pseudomonas aeruginosa) and.
P. amarus and P. sellowianus are closely related to P. niruri in appearance, phytochemical structure, and history of use, but typically are found in the drier tropical climates of India, Brazil, and even Florida and Texas. The Phyllanthus genus contains over 600 species of shrubs, trees, and annual or biennial herb Planting of Coleus forskohlii Phyllanthus amarus, with Phyllanthus amarus at a spacing of 90-30 × 30 cm and application of 40:60:50 kg NPK/ha + FYM 10 t/ha recorded significantly higher land equivalent ratio, crop equivalent yield and nutrient uptake Productivity followed by the application of poultry manure @ 3 t/ha dose dependent manner providing evidence for the traditional use of this herb for treatment/prevention of cancer. Notably, 350mg/kg body of both extracts showed better reduction of AFC compared to 250mg/kg body of both ethanolic and aqueous extracts of P amarus. Keywords: DMH (Dimethylhydrazine); Phyllanthus amarus An enriched hydrolyzable tannin blend derived from Phyllanthus amarus is provided.An optimized aqueous extraction method for Phyllanthus amarus is provided to maximize the levels of bioactive hydrolyzable tannins including corilagin, geraniin, nirurin and other low molecular weight hydrolyzable tannoids.The method produces a Phyllanthus amarus extract containing a hydrolyzable tannin blend as.
Phyllanthus amarus. Materials and Methods: The aqueous extract of Phyllanthus amarus was prepared using soxhlet apparatus. An in vivo study using Swiss albino mice was done to screen the central and peripheral analgesic activity of P.amarus extract. The extract was administered at a dose of 100 mg/kg body weight I.P. Th Pramehoushadhi is a patented anti-diabetic powder for the treatment of Type II Diabetes. This unique combination contains 14 herbs which are proven effective for the management of Diabetes. The chronic illness Diabetes requires long term therapy and Pramehoushadhi is designed to deliver the results without any harmful side effects. It prevents the diabetic patients t
The antiplasmodial effect of ethanolic leaf extract of Phyllanthus amarus on the biomarkers of renal function was investigated. The phytochemical constituents of the extract were screened. The renal function markers investigated include levels of uric acid, creatinine, urea and electrolytes (HCO3-, Na+, K+ and Cl-) in serum of Plasmodium berghei infected mice treated with P. amarus Phyllanthus amarus extract was shown to possess anticancer effects by inhibiting the solid and ascites tumor development in mice induced by Dalton's lymphoma ascites (DLA) cells and inhibiting cell growth and induced apoptosis in DLA cells through activation of caspase-3 and downregulation of Bcl-2 (Harikumar et al. 2009) Phyllanthus Species: Scientific Evaluation and Medicinal Applications. Phyllanthus Species. : Ramadasan Kuttan, K.B. Harikumar. CRC Press, Aug 29, 2011 - Health & Fitness - 388 pages. 0 Reviews. The genus Phyllanthus has over 1,000 species distributed worldwide, many of which have been used indigenously for the treatment of a variety of.
The P. amarus action was dose dependent where the highest effects observed in rats treated with a dose of 500 mg/kg bwt, and less effect with a low dose 200 mg/kg bwt. Figure 13: RT-PCR analysis of Glut-2 (a) and PEPCK (b) expression after oral administration of Phyllanthus amarus for 21 days to the STZ induced diabetic group Wistar rats as. The glycaemic response to 124.5 ± 9.3 (mean ± SD) g of pancakes was monitored in 21 non‐insulin dependent diabetic (NIDDM) patients while on oral hypoglycaemics, after a 1‐week washout period and after a 1‐week twice daily treatment with 100 mL of an aqueous extract from 12.5 g of powdered aerial parts of Phyllanthus amarus. After the 1‐week washout period, the fasting blood glucose. A preclinical study was performed to determine if the extract from Phyllanthus niruri (PN) plays a protective role against liver cirrhosis induced by thioacetamide (TAA) in rats. Initially, acute toxicity was tested and the results showed that the extract was benign when applied to healthy rats. Next, the therapeutic effect of the extract was investigated using five groups of rats: control.
In August 2013, the French pharmacopoeia was enriched with 43 plants used in French overseas territories, including 15 proposed by APLAMEDAROM association of Guadeloupe. However, for most of them, no data on the chemical composition, qualitatively and quantitatively is available in the literature for these specimens; this is an issue to their commercialization in dispensary, pharmacists. Phyllanthus amarus and related species are Indian plants that contain phyllanthin, hypophyllanthin and polyphenols with antiviral properties. Phyllanthus amarus whole plant powder administered at a dosage of 0.66 g/kg in rat showed hepatoprotective activity against CC[l.sub.4]-induced liver damage (Sane et al., 1995) A comparative study of Phyllanthus amarus compound and interferon in the treatment of chronic viral hepatitis B. Southeast Asian J Trop Med Public Health. 2001 Mar;32(1):140-2. 7. Srividya N, Periwal S. Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus For the most part, it is employed for similar conditions worldwide. This product is made from Phyllanthus Amarus. Antipyretic, pain-relief, etc. Its main uses are for many types of biliary and urinary conditions including kidney and gallbladder stones; for hepatitis, colds, flu, tuberculosis, and other viral infections; liver diseases and disorders including anemia, jaundice and liver cancer.